Hematoxylin

Name: Hematoxylin

CAS Registry Number: 517-28-2

CA Index Name: Benz[b]indeno[1,2-d]pyran-3,4,6a,9, 10(6H)-pentol, 7,11b-dihydro, (6aS,11bR)-

Other Names: cis-( + )-7,11b-Dihydrobenz[b]indeno [1,2-d]pyran-3,4,6a,9,10(6H)-pentol; Benz[b]indeno[1, 2-d]pyran-3,4,6a,9,10(6H)-pentol, 7,11b-dihydro; Benz [b]indeno[1,2-d]pyran-3,4,6a,9,10(6H)-pentol, C.I. 75290; C.I. Natural Black 1; 7,11b-Dihydro, (6aS-cis)-; Hematoxiline; (+ )-Hematoxylin; Haematoxylin; Hematoxylin; Hematoxyline; Hydroxybrasilin; Hydroxybrazilin; NSC 270085

Merck Index Number: 4637

Chemical / Dye Class: Flavone

Molecular Formula: C₁₆H₁₄O₆

Molecular Weight: 302.28

Physical Form: White to yellowish crystals turns red on exposure to light

Solubility: Soluble in water, ethanol, ethylene glycol, methyl cellosolve

Melting Point: 140 °C; 200 °C (decompose)

Boiling Point: 579.9 ± 50.0 °C, pressure: 760 Torr

pH Range: 0.0-1.0; 5.0-6.0

Color Change at pH: Red (0.0) to yellow (1.0); pale yellow (5.0) to violet (6.0)

Absorption (λ_max): 292 nm

Synthesis: Synthetic methods

Staining Applications: Aluminum; antigen; blood smears; cells; collagen; epithelial cells; eye lens; fish; genes; gluten structure; horny cells; lipid; liver tissues; malignant melanoma; myocardial biopsies; neurons; nucleic acids; nucleus; oil droplets; proteins; starch granules; tissues; hairs; keratin fibers

Biological Applications: Detecting breast cancer, collagen, genes, microorganism; treating age-related macular degeneration, burns, cancer, diabetes, obesity, gastroesophageal reflux disease, peripheral neural and vascular ailments, prostate cancers, skin disorders, viral diseases

Industrial Applications: Plasma display panel; textiles

Safety / Toxicity: Carcinogenicity; cytotoxicity; genotoxicity; mutagenicity; neurotoxicity; pulmonary toxicity

Certification / Approval: Certified by Biological Stain Commission (BSC)

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