Dansyl Cadaverine
Name: Dansyl Cadaverine
CAS Registry Number: 10121-91-2
CA Index Name: 1-Naphthalenesulfonamide, N-(5-aminopentyl)-5-(dimethylamino)-
Other Names: Dansylcadaverine; Monodansylcadaver-ine; N-(5-Aminopentyl)-5-dimethylamino-1-naphthale-nesulfonamide; 5-Dimethylaminonaphthalene-1-(N-(5-aminopentyl))sulfonamide
Merck Index Number: Not listed
Chemical / Dye Class: Naphthalene
Molecular Formula: C17H25N3O2S
Molecular Weight: 335.46
Physical Form: Yellow to yellowish green powder
Solubility: Soluble in ethanol, N,N-dimethylformamide
Melting Point: 137 °C
Boiling Point: 505.5 ± 60.0 °C, pressure: 760 Torr
pKa: 11.96 ± 0.50, most acidic, temperature: 25 °C; 10.49 ± 0.10, most basic, temperature: 25 °C
Absorption (λmax): 335 nm
Emission (λmax): 518 nm
Synthesis: Synthetic methods
Staining Applications: Autophagy/autophagic vacuoles; transglutaminase activity
Biological Applications: Measuring cardiac autophagic flux; treating cataract, fibrosis, Parkinson’s disease, peritoneal ovarian tumor dissemination, respiratory diseases, lung diseases, Huntington’s disease, spinobulbar atrophy, spinocerebellar ataxia, dentator-ubralpallidoluysian atrophy, multiple sclerosis, rheumatoid arthritis, insulin-dependent diabetes mellitus
Industrial Applications: Not reported
Safety / Toxicity: Cytotoxicity; neurotoxicity
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